Joint Centers of Excellence Program
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Hisham Alhadlaq

Assistant Professor of Medical Physics
College of Science
KSU

Hisham Alhadlaq has completed his Ph.D in Medical Physics from the US and has been an Assistant Professor of Medical Physics in the Department of Physics and Astronomy at King Saud University, Riyadh, Saudi Arabia since 2005. In 2010-2011, he was a Visiting Assistant Professor at the Department of Diagnostic Radiology and the Magnetic Resonance Research Center (MRRC) at Yale School of Medicine, New Haven, USA. His research interests include: high resolution polarized light microscopy imaging, magnetic resonance imaging (MRI), novel molecular imaging techniques, MRI shift and contrast agents, and nanoparticles as contrast and therapeutic agents.
Recently, his lab group has been focusing on evaluating the biocompatibility and toxicity of engineered nanoparticles and to test how these effects may be affected by nanoparticles’ unique physicochemical properties including crystalline nature, sizes and surface chemistry. His lab is also working on anticancer activity of nanoparticles. Recent preliminary results suggest that some metal nanoparticles have the potential to selectively kill cancer cells while posing very low toxicity to normal cells.
Affiliations
• Department of Physics and Astronomy, King Saud University
• King Abdullah Inst. for Nanotechnology (KAIN), King Saud University
Key Publications
Ahamed M, Alhadlaq H, Khan M,and Akhtar M. Selective killing of cancer cells by iron oxide nanoparticles mediated through reactive oxygen species via p53 pathway. J Nanoparticle Res 2013; 15 (2) 1-11.
Ahamed M, Siddiqui M, Akhtar M, Ahmad I, Pant A, and Alhadlaq H. Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells. BBRC 2010; 396 (2) 578-583.
Alhadlaq H, Xia Y, Hansen F, Les C, and Lust G. Morphological changes in articular cartilage due to static compression: polarized light microscopy study. Conn Tiss Res 2007; 48 (2): 76-84.
Alhadlaq H and Xia Y. Modifications of orientational dependence of microscopic magnetic resonance imaging T2 anisotropy in compressed articular cartilage. JMRI 2005; 22 (5): 665-673